Climate change poses serious risk to agricultural systems and the availability of food and other vital resources—from fuels to the raw materials used to develop everyday products. Canada is committed to ambitious action to advance climate change mitigation and adaptation. New technologies, products and approaches are required to reduce emissions, maintain productivity and competitiveness, and ensure food security at home and abroad. Genome Canada has evolved to investing in a challenge-driven portfolio of interdisciplinary research and innovation projects and connecting their efforts with cross-cutting programs for knowledge mobilization, data coordination, and implementation. This portfolio approach allows benefits from one solution to translate into other food systems/supply chains and cascade impact throughout the broader food system, ultimately strengthening the resiliency, sustainability, and economic viability of food production in Canada.