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Genome Sequencing - A Beaver's Tale

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JJR Macleod Auditorium

Medical Sciences Building

1 King's College Circle

Toronto, ON M5S 1A8

Canada

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Canada's Engineer - A Beaver's Tale

This talk describes the use of a difficult but useful form of genome sequencing called de novo sequencing, where the genome sequence is reconstructed from scratch without the shortcuts of current methods. De novo sequencing is particularly suited to the genomes of species that have previously not been sequenced. To celebrate Canada’s 150th anniversary, and as a part of our effort to develop de novo sequencing for clinical use, we completed and published the first genome sequence of the Canadian beaver (Castor canadensis), the country’s iconic national symbol that was the economic engine that drove early British and French colonial expansion leading to the founding of Canada.




Si Lok

Dr. Lok has nearly 30 years experience in research and discovery in the bio-industrial sector and academia. Trained in Medical Biophysics at the University of Toronto, he was Principal Scientist at ZymoGenetics, the research and discovery arm of the Danish pharmaceutical company, Novo Nordisk. There, he led a large functional cloning group that discovered the long sought and contested platelet growth factor, Thrombopoietin (TPO), and contributed to the cloning of the elusive glucagon receptor, a major mediator of glucose homeostasis.

Dr. Lok was an early practitioner of functional genomics, his group was one of the first in industry to use large-scale DNA sequencing and data mining to discover new biologic entities and drug targets. Moving to academia in 2003, Dr. Lok was the Chair Professor of Genomic Medicine and the Scientific Director of the Genome Research Centre at the University of Hong Kong where he focused on the translation of genomics into the clinic. Under the auspices of a grant from Genome Canada to develop disruptive technologies, Dr. Lok is currently working in the Centre for Applied Genomics of the Hospital for Sick Children.

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JJR Macleod Auditorium

Medical Sciences Building

1 King's College Circle

Toronto, ON M5S 1A8

Canada

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