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Leptin and the Biological Basis of Obesity w/ Dr. Jeffrey Friedman
Sun, 15 January 2017, 2:00 PM – 3:30 PM EST
The discovery of leptin has led to the elucidation of a robust physiologic system that maintains fat stores at a relatively constant level. Leptin is a peptide hormone secreted by adipose tissue. This hormone circulates in blood and acts on the hypothalamus to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. By such a mechanism total energy stores are stably maintained within a relatively narrow range.
In this talk, Dr. Jeffrey Friedman, a Professor at The Rockefeller University, and an Investigator for the Howard Hughes Medical Institute will discuss his discovery of the leptin hormone and how recessive mutation in the leptin gene is linked to obesity, infertility, diabetes and other immune abnormalities. He will also explore the several avenues by which leptin can be used to treat or correct an increasing number of human conditions.
Dr. Jeffrey Friedman is a physician scientist studying the genetic mechanisms that regulate body weight. His research on various aspects of obesity received national attention in late 1994, when it was announced that he and his colleagues had isolated the mouse ob gene and its human homologue. Since then, Dr. Friedman has received countless honours and awards for his contribution to science, including his most recent Harrington Prize for Innovation in Medicine in 2016.
This talk is presented in partnership with the Gairdner Foundation.