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Nanoparticle delivery systems for ruthenium-based therapeutics

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The Waegwoltic Club

6549 Coburg Road

Halifax, NS B3H 2A6

Canada

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The low toxicity and unique chemical properties of ruthenium have given rise to numerous therapeutic applications for this transition metal in medical imaging and the treatment of cancer and neurodegenerative disorders. This meeting will bring together Canadian and American experts in the medicinal chemistry and formulation of ruthenium-based compounds in lipid nanoparticles to improve drug delivery. Recent findings will be presented on how this therapeutic strategy can be applied to treat disorders characterized by impaired cell death and survival. A central theme of the morning session will be the role of mitochondrial dysfunction in cancer and neurodegeneration. Dr. Evgeny V. Pavlov (New York University) will describe mitochondrial mechanisms in neurodegeneration. The synthesis and protective properties of ruthenium-based inhibitors of the mitochondrial calcium uniporter (MCU) will be discussed next by Dr. Justin J. Wilson (Cornell University). Drs. Sherri McFarland (North Carolina University) and Shashi Gujar (Dalhousie University) will then describe the development and use of light-activated ruthenium complexes to induce mitochondrial-mediated and immunogenic cell death. This will be followed by a poster session during the lunch break. Dr. Marianna Foldvari (University of Waterloo) will begin the afternoon session by describing recent nanoparticle design strategies for intracellular drug delivery. Dr. S. Gadde (University of Ottawa) will then speak about nanomaterials for imaging and drug delivery. Next, Dr. David Lewis (Entos Pharmaceuticals) will then discuss recent developments in the use of fusion-enhancing proteins to improve cellular drug uptake. Lastly, Dr. George S. Robertson (Dalhousie University) will speak about a new approach to reduce reperfusion brain injury after thrombolytic therapy for ischemic stroke by the local delivery of a ruthenium-based MCU inhibitor encapsulated in lipid nanoparticles.

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The Waegwoltic Club

6549 Coburg Road

Halifax, NS B3H 2A6

Canada

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