Presenter: Ms. Rishma Chooniedass, RN, MN
Title: Caregivers’ lived experience of their child’s anaphylactic reactions: An interpretive phenomenology
Abstract: Children with life threatening food allergies live with the constant threat of a fatal reaction, and caregivers must be prepared to treat with an epinephrine auto-injector (EAI). Morbidity and mortality are associated with a delay or lack of epinephrine use and it is well documented that rates of epinephrine use during an anaphylactic reaction are alarmingly low. An interpretive phenomenology explored caregivers’ perceptions and lived experiences with prescribed EAI use for their child’s anaphylactic reaction. The purposive sample consisted of 11 caregivers of children under the age of 12, diagnosed with a food allergy, prescribed an EAI and who experienced an anaphylactic reaction within the last two years. In-depth, semi-structured interviews were audio-recorded and transcribed verbatim. Nvivo software was used to organize and manage the data and interpretive phenomenological analysis was performed. Eight main themes emerged: perception of anaphylaxis, life challenges, isolation, anxiety, hesitation, guilt, influence of health care, and lessons learned. Caregivers explained the multiple life challenges and feelings of isolation. During reactions, caregivers identified anxiety and hesitation that lead to subsequent guilt. They shared an uncertainty in discerning if the child was experiencing anaphylaxis, which led to waiting for the situation to spontaneously improve. Some participants shared that handling reactions correctly provided them with confidence to treat subsequent reactions. Witnessing the rapid effects of EAI and receiving positive support from health care providers further facilitated caregivers’ abilities and confidence to quickly and competently intervene in future reactions. Findings have been incorporated into innovative educational tools for caregivers of children with food allergies.
Presenter: Ms. Jane Karpa, RPN, MMFT, PhD (c), Assistant Professor, Chair, Department of Psychiatric Nursing, Brandon University, Faculty of Health Studies
Title: Families’ Experiences Living with Acquired Brain Injury: A Narrative Inquiry Study
Abstract: Notoriously known as the ‘silent epidemic’, Acquired Brain Injury (ABI) has reached worldwide epidemic proportions. While ABIs are manifested in individuals, families’ lives are dramatically affected by ABIs. Individuals with an ABI can experience a range of cognitive, behavioural and emotional impairments, often not visible, that may cause significant disruptions/changes to their psycho-social presence and identity. These post ABI changes can directly impact individuals’ and families’ experiences and lead to an overwhelming sense of loss. The purpose of this research study is to examine families’ experiences living with ABI. The research question is: How do families make sense of their experiences living with ABI? This study will be guided by ambiguous loss theory and use a research approach that includes both the affected individual family member and the family together as a family group. This will be a qualitative narrative study. The purpose of narrative inquiry is to capture and examine the stories people tell to explain their lives. Families build stories/narratives from reflecting on how they make sense of their world, express rules of interaction and create beliefs about relationships. Narrative inquiry emphasizes meaning development through the characteristics of relatedness, identity and time; therefore it is a useful methodology for examining families affected by an ABI. While narrative inquiry within the social sciences has been utilized extensively with individuals and groups, its application to investigations with families as a unit is unique. The purpose of this oral presentation is to provide an overview of the background, conceptual framework, and methodology of this successfully defended PhD thesis proposal.
Presenter: Dr. Joseph Gordon, Assistant Professor, College of Nursing, University of Manitoba
Title: Evaluation of clenbuterol therapy to reverse mitochondrial dysfunction induced by exposure to gestational diabetes
Abstract: Recent evidence has revealed that exposure to gestational diabetes during fetal development alters skeletal muscle metabolism in offspring, which increases the risk for insulin resistance later in life. Despite the clinical relevance, the key molecular players responsible for this observation are not understood. My laboratory recently discovered a genetic pathway that becomes disrupted in skeletal muscle of rodents exposed to gestational diabetes, resulting in increased expression of a mitochondrial inhibitor gene called Nix. Furthermore, we have data suggesting that the Nix function can be inhibited by clenbuterol treatment. Our objective is to evaluate if clenbuterol can reverse Nix-induced skeletal muscle metabolic derangement. To achieve this, we utilize a unique cell culture model that mimics the development of skeletal muscle. These molecular studies are necessary and form the foundation of a larger program of research defining the biological role of Nix and testing the utility of clenbuterol therapy.