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Dorothy J. Killam Lecture

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The Neuro, Montreal Neurological Institute – Hospital

3801 Rue Université

Jeanne Timmins Amphitheatre

Montréal, QC H3A 2B4

Canada

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Event description
Cell type classification and circuit mapping in the mouse brain

About this Event

The Neuro's DJK Lecture was established in 2004 to recognize women of influence in business, science, politics or the humanities.

The 2021 Dorothy J. Killam Lecture will be delivered by Hongkui Zeng, Executive Vice President and Director of Allen Institute for Brain Science, Seattle, USA. Her lecture is titled "Cell type classification and circuit mapping in the mouse brain”. A reception will follow.

Talk Abstract

To understand the function of the brain and how its dysfunction leads to brain diseases, it is essential to have a deep understanding of the cell type composition of the brain, how the cell types are connected with each other and what their roles are in circuit function. At the Allen Institute, we have built multiple platforms, including single-cell transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, high throughput brain-wide connectivity mapping, and large-scale neuronal activity imaging, to characterize the transcriptomic, physiological, morphological, and connectional properties of different types of neurons in a standardized way, towards a taxonomy of cell types and a description of their wiring diagram for the mouse brain, with a focus on the visual cortico-thalamic system. Building such knowledge base lays the foundation towards the understanding of the computational mechanisms of brain circuit function.

Speaker Bio:

Hongkui Zeng is Executive Vice President and Director of Allen Institute for Brain Science. Since joining the Allen Institute in 2006, she has led several efforts to develop and operate high-throughput pipelines to generate large-scale, open-access datasets and tools to accelerate neuroscience discovery. Her current research interests are in understanding neuronal diversity and connectivity in the mouse brain-wide circuits and how different cell types work together to process and transform information. Through her leadership of multiple scientific teams at the Allen Institute for Brain Science, she has built several research programs, including the Allen Mouse Brain Connectivity Atlas and the Mouse Cell Types Program, to explore different properties of brain cells, all working toward the goal of creating a census and taxonomy of cell types and understanding their connectivity in mammalian brains. Zeng received her Ph.D. in molecular and cell biology from Brandeis University, where she studied the molecular mechanisms of the circadian clock in fruit flies. As a postdoctoral fellow at Massachusetts Institute of Technology, she studied the molecular and synaptic mechanisms underlying hippocampus-dependent plasticity and learning. She has received many honors, including the 2016 AWIS Award for Scientific Advancement and the 2018 Gill Transformative Investigator Award.

https://alleninstitute.org/what-we-do/brain-science/about/team/staff-profiles/hongkui-zeng/

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Date and Time

Location

The Neuro, Montreal Neurological Institute – Hospital

3801 Rue Université

Jeanne Timmins Amphitheatre

Montréal, QC H3A 2B4

Canada

View Map

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